Diagnostic and therapeutic antibody conjugates
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United States of America Patent
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Oct 15, 1991
Issued Date -
N/A
app pub date -
Aug 23, 1988
filing date -
Feb 25, 1986
priority date (Note) -
Expired
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Abstract
The present invention relates to conjugates of diagnostic or therapeutic principles, such as drugs, toxins, chelators, boron compounds and detectable labels, to an antibody, in which the diagnostic or therapeutic principle is first loaded onto a polymer carrier such as an aminodextran or a polypeptide of at least 50 amino acids in length, and this intermediate is in turn site-specifically conjugated to a targeting antibody such as an antitumor antibody. The resultant conjugate substantially retains the immunoreactivity of the antibody, and targets the diagnostic or therapeutic principle to a target tissue or organ where the diagnostic or therapeutic effect is realized.
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