Corticotropin-releasing factor antagonism compounds
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United States of America Patent
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Nov 5, 1991
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N/A
app pub date -
Mar 28, 1990
filing date -
Mar 28, 1990
priority date (Note) -
Expired
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Abstract
The present invention relates to a method of producing corticotropin-releasing factor (CRF) antagonist activity and thus provides a method of treating a wide range of stress-related disorders, including affective illnesses, such as depression and anxiety, as well as irritable bowel syndrome, anorexia nervosa, cardiovascular abnormalities and stress-induced immune suppression. The invention also relates to compounds (4-substituted thio-5-oxo-3-pyrazolines) and to pharmaceutical compositions suitable for use in such a method.
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