N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
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United States of America Patent
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Nov 19, 1991
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N/A
app pub date -
Oct 6, 1989
filing date -
Apr 24, 1987
priority date (Note) -
Expired
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Abstract
A series of 15 N.sup.6 -substituted 9-methyladenines have been assessed as antagonists of A.sub.2 -adenoisine receptor-mediated stimulation of adenylate cyclase in membranes of hman platelets and rat PC12 cells and of A.sub.1 -adenosine receptor-mediated inhibition of adenylate cyclases in membranes of rat fat cells and as inhibitors of binding of N.sup.6 -R-[.sup.3 H]-phenylisopropyladenosine to A.sub.1 adenosine receptors in rat brain membranes.
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