Gene probe for detection of specific human leukemias
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United States of America Patent
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Nov 19, 1991
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N/A
app pub date -
Dec 2, 1988
filing date -
Sep 4, 1987
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Abstract
Gene probes containing genetic sequences that code for proteins which are phenotypically characteristic of certain leukemias, such as chronic myelogenous leukemia, can be prepared from RNA of a person having that disease. A useful probe has been found which comprises a sequence localized to chromosome 8, the sequence being complementary to a mRNA that is characteristically present in high abundance in chronic myelogenous leukemia cells. The gene probes can be used in diagnostic hybridization tests with RNA or a patient to be diagnosed.
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