Production of the E. coli LT-B enterotoxin subunit in S. typhi
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United States of America Patent
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Jan 7, 1992
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N/A
app pub date -
Jun 29, 1988
filing date -
Jun 29, 1988
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Expired
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Abstract
Methods and compositions are provided for the cloning and expression of plasmids bearing genes coding for the non-toxic subunit of the heat-laible enterotoxin (LT-B) of E. coli. These plasmids may be cloned into stable avirulent strains of Salmonella typhi and used to make oral bivalent vaccines. Such vaccines may be used to prevent typhoid fever and cholera-like enterotoxin-induced diarrheal disease.
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