Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond
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United States of America Patent
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Feb 4, 1992
Issued Date -
N/A
app pub date -
Feb 7, 1991
filing date -
Mar 8, 1989
priority date (Note) -
Expired
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Abstract
Disclosed herein are compounds of the class of peptides having from about 4 to about 8 amino acid residues that are substrates for retroviral protease, e.g., HIV protease, derived from known cleavage sites and that are modified to contain an internal COCH.sub.2 bond isostere, useful as inhibitors of said retroviral protease, e.g., HIV protease, and exemplified by the modified peptide, Abz-Thr-Ile-Nle.PSI.(K)Nle-Gln-Arg-NH.sub.2, wherein K is COCH.sub.2.
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