US Patent No: 5,087,244

Number of patents in Portfolio can not be more than 2000

Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen

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Importance

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Abstract

A method and catheter for use in practicing the method are provided by which a highly concentrated medication or chemotherapeutic agent can be applied locally under sufficient pressure to cause the medication or agent to penetrate into the localized tissue. The total volume of medication or agent is quite small, well below levels that might cause an adverse reaction in other parts of the body. The catheter includes a thin walled flexible balloon having a plurality of minute holes through which medication may flow at a low flow rate. The balloon is inflated with the medication under pressure and the flow rate of the order of a few ccs per minute is controlled by the minute holes in the balloon. In practicing the method of the invention, the balloon is selected such that its inflated diameter will correspond to or be slightly greater than the diameter of the lumen into which it is to be placed so that when the balloon is inflated, it will contact intimately the surface of the lumen. Inflation of the balloon with the medication will cause a thin film to spread between the balloon and the lumen, the film being maintained under a sufficient pressure to penetrate significantly the surrounding tissue with a high concentration of medication. The quantity of medication that ultimately flows free into the lumen is quite small and is insufficient to cause any other damage to the patient.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
C.R. BARD, INC.MURRAY HILL, NJ680

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barbere, Michael D Dunstable, MA 24 930
King, Spencer L Atlanta, GA 1 251
Wolinsky, Harvey New York, NY 3 704

Cited Art

Patent Info (Count) # Cites Year
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (3)
4,323,071 Vascular guiding catheter assembly and vascular dilating catheter assembly and a combination thereof and methods of making the same 499 1980
4,782,834 Dual lumen dilatation catheter and method of manufacturing the same 166 1987
4,821,722 Self-venting balloon dilatation catheter and method 100 1987
 
BOSTON SCIENTIFIC SCIMED, INC. (1)
4,994,033 Intravascular drug delivery dilatation catheter 336 1989
 
Hanover; George (1)
4,327,721 Endotracheal tube with topical agent delivery system and method of using the same 81 1979
 
MEDTRONIC INTERVENTIONAL VASCULAR, INC. (1)
4,917,666 Steerable thru-lumen catheter 104 1988
 
Other [Check patent profile for assignment information] (6)
4,211,233 Urethral catheter 45 1978
4,437,856 Peritoneal catheter device for dialysis 86 1981
4,417,576 Double-wall surgical cuff 168 1982
4,423,725 Multiple surgical cuff 421 1982
4,636,195 Method and apparatus for removing arterial constriction 219 1985
4,693,243 Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas 116 1986

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (33)
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5,415,637 Temporary stenting catheter with drug delivery capabilities 63 1993
5,611,775 Method of delivery therapeutic or diagnostic liquid into tissue surrounding a body lumen 108 1994
5,626,562 Drug delivery catheter 52 1994
5,865,794 Drug delivery catheter 18 1997
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6,544,223 Balloon catheter for delivering therapeutic agents 181 2001
6,764,505 Variable surface area stent 248 2001
7,862,495 Radiation or drug delivery source with activity gradient to minimize edge effects 1 2001
6,706,013 Variable length drug delivery catheter 110 2001
7,169,178 Stent with drug coating 52 2002
7,115,299 Balloon catheter for delivering therapeutic agents 12 2003
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7,169,173 Composite stent with regioselective material and a method of forming the same 19 2003
7,198,675 Stent mandrel fixture and method for selectively coating surfaces of a stent 48 2003
7,563,324 System and method for coating an implantable medical device 21 2003
7,674,493 Method of making a variable surface area stent 1 2004
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7,077,860 Method of reducing or eliminating thrombus formation 15 2004
7,297,159 Selective coating of medical devices 4 2004
7,648,727 Methods for manufacturing a coated stent-balloon assembly 1 2004
7,632,307 Abluminal, multilayer coating constructs for drug-delivery stents 4 2004
7,867,547 Selectively coating luminal surfaces of stents 0 2005
8,003,156 Rotatable support elements for stents 2 2006
7,658,966 Balloon catheter for delivering therapeutic agents 3 2006
7,824,440 Stent with drug coating 2 2006
7,824,441 Stent with drug coating 2 2006
7,820,229 Method of coating a stent 2 2006
7,666,223 Stent with drug coating 3 2006
8,197,879 Method for selectively coating surfaces of a stent 0 2007
7,604,700 Stent mandrel fixture and method for selectively coating surfaces of a stent 1 2007
8,119,184 Method of making a variable surface area stent 0 2010
8,293,367 Nanoshells on polymers 0 2011
 
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7,720,521 Methods and devices for performing procedures within the ear, nose, throat and paranasal sinuses 7 2005
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8,114,113 Multi-conduit balloon catheter 0 2005
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7,419,497 Methods for treating ethmoid disease 37 2006
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8,118,757 Methods and devices for ostium measurement 0 2007
8,146,400 Endoscopic methods and devices for transnasal procedures 0 2007
8,088,101 Devices, systems and methods for treating disorders of the ear, nose and throat 0 2007
8,123,722 Devices, systems and methods for treating disorders of the ear, nose and throat 4 2007
8,172,828 Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures 0 2007
8,090,433 Methods and apparatus for treating disorders of the ear nose and throat 0 2007
8,080,000 Methods and apparatus for treating disorders of the ear nose and throat 0 2007
7,785,315 Methods for irrigation of ethmoid air cells and treatment of ethmoid disease 2 2007
8,142,422 Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat 1 2008
8,182,432 Corewire design and construction for medical devices 0 2008
8,100,933 Method for treating obstructed paranasal frontal sinuses 0 2008
8,388,642 Implantable devices and methods for treating sinusitis and other disorders 0 2008
8,414,473 Methods and apparatus for treating disorders of the ear nose and throat 0 2009
8,114,062 Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders 0 2009
8,425,457 Devices, systems and methods for diagnosing and treating sinusitus and other disorder of the ears, nose and/or throat 0 2009
8,435,290 System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx 0 2010
 
BOSTON SCIENTIFIC SCIMED, INC. (22)
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5,797,877 Medical device balloons containing thermoplastic elastomers 165 1996
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6,132,824 Multilayer catheter balloon 46 1997
7,087,039 Perfusion balloon angioplasty catheter 0 1997
6,299,597 Percutaneous repair of cardiovascular anomalies and repair compositions 52 1997
6,086,556 Medical device balloons containing thermoplastic elastomers 45 1998
6,482,348 Method of forming a co-extruded balloon for medical purposes 28 2000
6,896,842 Medical device balloons containing thermoplastic elastomers 13 2000
7,613,503 Device with infusion holes for imaging inside a blood vessel 0 2002
8,317,747 Catheter for tissue dilation and drug delivery 0 2004
7,781,038 Medical device balloons containing thermoplastic elastomers 1 2004
7,371,257 Stent lining 2 2004
7,632,242 Catheter including a compliant balloon 1 2004
7,585,289 Co-extruded medical balloon 0 2005
8,021,329 Catheter including a compliant balloon 0 2009
 
MEDTRONIC, INC. (10)
5,112,303 Tumor access device and method for delivering medication into a body cavity 70 1991
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5,893,840 Releasable microcapsules on balloon catheters 115 1996
6,551,290 Catheter for target specific drug delivery 43 2000
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6,510,348 Perfusion lead and method of use 5 2000
6,697,677 System and method for placing a medical electrical lead 30 2001
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7,153,292 Catheter for target specific drug delivery 1 2004
 
CORDIS CORPORATION (8)
5,213,576 Therapeutic porous balloon catheter 238 1991
6,146,358 Method and apparatus for delivery of therapeutic agent 113 1992
5,318,531 Infusion balloon catheter 102 1992
5,405,472 Method of making infusion balloon catheter 38 1993
5,674,198 Tandem balloon catheter 54 1995
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5,833,659 Infusion balloon catheter 70 1996
6,616,650 Method and apparatus for delivery of therapeutic agent 29 2000
 
VENTION MEDICAL ADVANCED COMPONENTS, INC. (8)
5,286,254 Drug delivery apparatus and method 329 1992
5,282,785 Drug delivery apparatus and method 211 1992
5,498,238 Simultaneous angioplasty and phoretic drug delivery 105 1993
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5,628,730 Phoretic balloon catheter with hydrogel coating 286 1994
5,807,306 Polymer matrix drug delivery apparatus 250 1994
5,569,198 Microporous catheter 68 1995
5,800,392 Microporous catheter 231 1996
 
ATRIUM MEDICAL CORPORATION (7)
6,955,661 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 51 1999
6,395,208 Method of making an expandable fluoropolymer device 43 1999
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8,021,331 Method of coating a folded medical device 1 2005
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8,308,684 Method of coating a folded medical device 0 2011
 
J.W. MEDICAL SYSTEMS LTD. (7)
5,571,086 Method and apparatus for sequentially performing multiple intraluminal procedures 176 1994
7,147,655 Balloon catheter for multiple adjustable stent deployment 25 2002
8,157,851 Apparatus and methods for deployment of multiple custom-length prostheses 0 2005
7,938,851 Devices and methods for operating and controlling interventional apparatus 1 2005
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8,147,536 Balloon catheter for multiple adjustable stent deployment 0 2009
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W. L. GORE & ASSOCIATES, INC. (7)
5,752,934 Balloon catheter device 76 1995
5,868,704 Balloon catheter device 78 1996
6,120,477 Balloon catheter device 143 1997
7,892,201 Balloon catheter and method of mounting same 0 1999
6,923,827 Balloon catheter device 11 2002
8,460,240 Inflatable toroidal-shaped balloons 0 2006
7,785,290 Non-shortening high angle wrapped balloons 2 2006
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (6)
8,048,448 Nanoshells for drug delivery 0 2006
8,017,237 Nanoshells on polymers 0 2006
8,025,916 Methods for forming a composite stent with regioselective material 0 2006
8,048,441 Nanobead releasing medical devices 0 2007
8,277,868 Balloon catheter for delivering therapeutic agents 0 2009
8,440,090 Apparatus and method of making a variable stiffness multilayer catheter tubing 0 2010
 
LOCALMED, INC. (6)
5,279,565 Intravascular treatment apparatus and method 157 1993
5,609,574 Intravascular catheter with infusion array 59 1994
5,536,250 Perfusion shunt device and method 56 1994
5,562,620 Perfusion shunt device having non-distensible pouch for receiving angioplasty balloon 44 1995
5,713,860 Intravascular catheter with infusion array 56 1995
5,599,306 Method and apparatus for providing external perfusion lumens on balloon catheters 87 1995
 
MEDTRONIC AVE, INC. (6)
5,904,670 Catheters and methods for guiding drugs and other agents to an intended site by deployable grooves 36 1996
6,280,413 Thrombolytic filtration and drug delivery catheter with a self-expanding portion 134 1997
5,854,822 Miniature x-ray device having cold cathode 40 1997
6,108,402 Diamond vacuum housing for miniature x-ray device 44 1998
6,069,938 Method and x-ray device using pulse high voltage source 27 1998
6,958,059 Methods and apparatuses for drug delivery to an intravascular occlusion 17 2001
 
ANGIODYNAMICS, INC. (5)
7,585,836 Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy 0 2005
7,993,325 Renal infusion systems and methods 0 2005
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7,771,401 Selective renal cannulation and infusion systems and methods 0 2007
8,012,121 Method and apparatus for selective material delivery via an intra-renal catheter 2 2007
 
AD-TECH MEDICAL INSTRUMENT CORPORATION (4)
7,241,283 Method for intracranial catheter treatment of brain tissue 14 2003
7,465,292 Catheter system for intracranial treatment 4 2005
7,322,954 Catheter assembly for intracranial treatment using dual lumens 4 2005
7,255,686 Catheter assembly for intracranial treatment 4 2005
 
SCIMED LIFE SYSTEMS, INC. (4)
5,558,642 Drug delivery catheter 90 1994
5,716,340 Blood perfusion catheter 37 1996
6,409,716 Drug delivery 75 1997
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CARDIOVASCULAR DYNAMICS, INC. (3)
5,295,962 Drug delivery and dilatation catheter 120 1992
5,569,215 Low profile infusion catheter 23 1995
5,569,184 Delivery and balloon dilatation catheter and method of using 71 1995
 
EDWARDS LIFESCIENCES CORPORATION (3)
6,685,672 Multi-balloon drug delivery catheter for angiogenesis 7 2000
6,692,458 Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis 37 2000
6,997,898 Multi-balloon drug delivery catheter for angiogenesis 9 2004
 
INTERSECT ENT, INC. (3)
7,547,323 Stent for irrigation and delivery of medication 8 2006
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KENSEY NASH CORPORATION (3)
6,709,427 Systems and methods for delivering agents into targeted tissue of a living being 20 1999
7,594,900 Systems and methods for delivering agents into targeted tissue of a living being 0 2002
7,419,482 Systems and methods for delivering agents into targeted tissue of a living being 0 2004
 
STRYKER NV OPERATIONS LIMITED (3)
6,623,452 Drug delivery catheter having a highly compliant balloon with infusion holes 40 2000
7,758,541 Targeted drug delivery device and method 10 2004
8,206,346 Targeted drug delivery device and method 0 2010
 
VEGENICS PTY LTD (3)
6,958,147 Use of VEGF-C to prevent restenosis 9 1999
8,455,453 Use of VEGF-D gene to prevent restenosis 0 2005
8,278,098 Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins 0 2011
 
ABBOTT LABORATORIES (2)
8,236,039 Vena cava filter having wall contacts 0 2008
8,292,913 Method of reducing rigidity of angioplasty balloon sections 0 2011
 
APPLIED MEDICAL TECHNOLOGY, INC. (2)
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8,382,664 Molded and undivided medical penetrating device 0 2011
 
BOSTON SCIENTIFIC CORPORATION (2)
6,494,861 Drug delivery system 9 1997
5,868,719 Drug delivery balloon catheter device 43 1997
 
Cardeon Corporation (2)
6,267,747 Aortic catheter with porous aortic root balloon and methods for inducing cardioplegic arrest 29 1999
6,835,188 Aortic catheter with porous aortic root balloon and methods for inducing cardioplegic arrest 2 2001
 
DynamOx, Inc. (2)
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Endoluminal Therapeutics, Inc. (2)
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ETHICON, INC. (2)
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GORE ENTERPRISE HOLDINGS, INC. (2)
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JPMORGAN CHASE BANK, N.A. (2)
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6,682,555 Methods for treating the prostate and inhibiting obstruction of the prostatic urethra using biodegradable stents 18 2001
 
KIMBERLY-CLARK WORLDWIDE, INC. (2)
7,465,291 Method of fluid delivery and catheters for use with same 7 2003
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MICRO THERAPEUTICS, INC. (2)
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SYNTHES USA, LLC (2)
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THEROX, INC. (2)
6,235,007 Atraumatic fluid delivery devices 43 1998
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VEIN RX, INC. (2)
7,077,836 Methods and apparatus for sclerosing the wall of a varicose vein 6 2001
8,157,747 Single-use indicator for a surgical instrument and a surgical instrument incorporating same 0 2008
 
XRT CORP. (2)
5,713,853 Methods for treating thrombosis 103 1995
6,799,075 X-ray catheter 25 1996
 
ABACUS DESIGN & DEVELOPMENT, INC. (1)
5,653,689 Infusion catheter 66 1995
 
ADGERO BIOPHARMACEUTICALS, INC. (1)
7,396,354 Light delivery catheter 2 2003
 
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. (1)
5,306,250 Method and apparatus for intravascular drug delivery 144 1992
 
AMS RESEARCH CORPORATION (1)
8,262,605 Needleless delivery systems 0 2005
 
Angio Dynamics (1)
7,914,503 Method and apparatus for selective material delivery via an intra-renal catheter 0 2005
 
BARD CONNAUGHT (1)
6,048,332 Dimpled porous infusion balloon 53 1998
 
BOSTON SCIENTIFIC LIMITED (1)
6,306,166 Loading and release of water-insoluble drugs 129 1998
 
BRAINLAB AG (1)
6,464,662 Drug delivery and catheter systems, apparatus and processes 10 2000
 
BY-PASS INC. (1)
8,439,890 Material delivery system 0 2011
 
CARDIAC PACEMAKERS, INC. (1)
7,765,015 Lead with inflatable fixation mechanism 0 2007
 
CARDIO VASCULAR DYNAMICS (1)
5,368,566 Delivery and temporary stent catheter having a reinforced perfusion lumen 133 1992
 
CARDIOCOMMAND, INC. (1)
6,148,222 Esophageal catheters and method of use 81 1998
 
COVIDIEN LP (1)
6,936,025 Thrombolysis device 17 2000
 
DEKA PRODUCTS LIMITED PARTNERSHIP (1)
6,168,609 Catamenial collector and methods of use 5 1998
 
DURECT CORPORATION (1)
7,438,701 Local concentration management system 0 2001
 
ENDOVASCULAR TECHNOLOGIES, INC. (1)
6,702,802 Catheters with improved transition 24 2000
 
ERBE ELEKTROMEDIZIN GMBH (1)
6,752,799 Method and device for endoscopic injection of at least one fluid 0 1999
 
GANZ, ROBERT A. (1)
6,095,966 X-ray device having a dilation structure for delivering localized radiation to an interior of a body 72 1998
 
GE MARQUETTE MEDICAL SYSTEMS, INC. (1)
6,104,941 Physiological sensor 5 1998
 
INTERVENTIONAL INNOVATION CORPORATION (1)
6,377,846 Device for delivering localized x-ray radiation and method of manufacture 16 1997
 
JAGOTEC AG (1)
6,852,708 Use of hyaluronic acid and forms to prevent the narrowing of the vascular walls 0 1997
 
JOMED GMBH (1)
6,726,674 Methods for minimally invasive, localized delivery of sclerotherapeutic agents 6 2001
 
LARY RESEARCH & DEVELOPMENT, LLC (1)
7,985,200 Apparatus for delivering an intravascular drug 1 2006
 
Loyola University of Chicago (1)
5,599,307 Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities 120 1995
 
MATRIGEN, INC. (1)
5,833,658 Catheters for the delivery of solutions and suspensions 45 1996
 
MEDTRONIC VASCULAR, INC. (1)
7,753,876 Expandable jaw drug delivery catheter 0 2004
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
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NEOMEND, INC. (1)
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OLYMPUS OPTICAL CO., LTD. (1)
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PINPOINT THERAPEUTICS, INC. (1)
6,699,231 Methods and apparatus for perfusion of isolated tissue structure 50 1998
 
Radiance Medical Systems, Inc. (1)
6,027,487 Low profile infusion catheter 7 1996
 
SCHNEIDER (USA) INC. (1)
5,772,632 Dilation-drug delivery catheter 35 1997
 
SciMed (1)
5,554,119 Drug delivery catheter with manifold 177 1994
 
SHERWOOD SERVICES AG (1)
5,269,755 Catheter with outer membrane medicament delivery system 76 1992
 
Surgical Systems & Instruments, Inc. (1)
5,306,244 Method of guidewire insertion 46 1991
 
TERUMO KABUSHIKI KAISHA (1)
5,547,472 Catheter with medicament injection pores 39 1995
 
VASCULAR BIOGENICS LTD. (1)
8,415,318 Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy 0 2011
 
VASCULAR INSIGHTS LLC (1)
7,967,834 Vascular treatment device 1 2007
 
YALE UNIVERSITY (1)
7,862,575 Vascular ablation apparatus and method 1 2003
 
Other [Check patent profile for assignment information] (7)
5,498,251 Tissue perfusion catheter 13 1994
5,674,239 Intravaginal balloon for blood leakage prevention 14 1995
6,053,900 Apparatus and method for delivering diagnostic and therapeutic agents intravascularly 64 1998
7,621,908 Catheter for manipulation of the esophagus 2 2005
8,465,508 Vascular ablation apparatus and method 0 2007
8,328,771 Method for fluid delivery and catheters for use with same 0 2011
8,465,789 Rotatable support elements for stents 0 2011