US Patent No: 5,087,244

Number of patents in Portfolio can not be more than 2000

Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen

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Abstract

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A method and catheter for use in practicing the method are provided by which a highly concentrated medication or chemotherapeutic agent can be applied locally under sufficient pressure to cause the medication or agent to penetrate into the localized tissue. The total volume of medication or agent is quite small, well below levels that might cause an adverse reaction in other parts of the body. The catheter includes a thin walled flexible balloon having a plurality of minute holes through which medication may flow at a low flow rate. The balloon is inflated with the medication under pressure and the flow rate of the order of a few ccs per minute is controlled by the minute holes in the balloon. In practicing the method of the invention, the balloon is selected such that its inflated diameter will correspond to or be slightly greater than the diameter of the lumen into which it is to be placed so that when the balloon is inflated, it will contact intimately the surface of the lumen. Inflation of the balloon with the medication will cause a thin film to spread between the balloon and the lumen, the film being maintained under a sufficient pressure to penetrate significantly the surrounding tissue with a high concentration of medication. The quantity of medication that ultimately flows free into the lumen is quite small and is insufficient to cause any other damage to the patient.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
C. R. BARD, INC.MURRAY HILL, NJ658

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barbere, Michael D Dunstable, MA 20 1340
King, Spencer L Atlanta, GA 1 341
Wolinsky, Harvey New York, NY 3 842

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (20)
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6,685,672 Multi-balloon drug delivery catheter for angiogenesis 11 2000
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8,236,039 Vena cava filter having wall contacts 4 2008
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8,048,441 Nanobead releasing medical devices 4 2007
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8,277,868 Balloon catheter for delivering therapeutic agents 1 2009
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8,925,177 Methods for improving stent retention on a balloon catheter 2 2012
8,592,036 Nanoshells on polymers 0 2012
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8,808,342 Nanoshell therapy 0 2013
 
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6,955,661 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 87 1999
6,395,208 Method of making an expandable fluoropolymer device 50 1999
7,637,886 Expandable fluoropolymer device and method of making 5 2002
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8,021,331 Method of coating a folded medical device 2 2005
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* 2011/0213,302 METHOD OF COATING A FOLDED MEDICAL DEVICE 0 2011
 
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8,047,986 Molded and undivided medical penetrating device 0 2007
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6,702,802 Catheters with improved transition 50 2000
 
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LOCALMED, INC. (6)
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ADGERO BIOPHARMACEUTICALS, INC. (1)
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6,136,258 Method of forming a co-extruded balloon for medical purposes 80 1995
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5,797,877 Medical device balloons containing thermoplastic elastomers 212 1996
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6,086,556 Medical device balloons containing thermoplastic elastomers 62 1998
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6,896,842 Medical device balloons containing thermoplastic elastomers 34 2000
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7,371,257 Stent lining 18 2004
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8,090,433 Methods and apparatus for treating disorders of the ear nose and throat 21 2007
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8,142,422 Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat 47 2008
8,182,432 Corewire design and construction for medical devices 1 2008
8,864,787 Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis 1 2008
9,039,680 Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders 0 2008
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8,388,642 Implantable devices and methods for treating sinusitis and other disorders 26 2008
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9,101,384 Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat 1 2009
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8,764,726 Devices, systems and methods useable for treating sinusitis 3 2009
9,039,657 Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders 0 2009
* 2010/0114,066 IMPLANTABLE DEVICES AND METHODS FOR DELIVERING DRUGS AND OTHER SUBSTANCES TO TREAT SINUSITIS AND OTHER DISORDERS 69 2009
8,414,473 Methods and apparatus for treating disorders of the ear nose and throat 37 2009
* 2010/0099,946 METHODS AND APPARATUS FOR TREATING DISORDERS OF THE EAR NOSE AND THROAT 14 2009
8,114,062 Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders 23 2009
9,351,750 Devices and methods for treating maxillary sinus disease 0 2009
8,425,457 Devices, systems and methods for diagnosing and treating sinusitus and other disorder of the ears, nose and/or throat 34 2009
* 2010/0100,181 DEVICES, SYSTEMS AND METHODS FOR DIAGNOSING AND TREATING SINUSITUS ANDOTHER DISORDERS OF THE EARS, NOSE AND/OR THROAT 8 2009
8,828,041 Devices, systems and methods useable for treating sinusitis 3 2010
* 2010/0174,308 DEVICES, SYSTEMS AND METHODS USEABLE FOR TREATING SINUSITIS 55 2010
9,055,965 Devices, systems and methods useable for treating sinusitis 1 2010
8,435,290 System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx 5 2010
* 2010/0305,697 System and Method For Treatment of Non-Ventilating Middle Ear by Providing a Gas Pathway Through the Nasopharynx 1 2010
8,852,143 Devices, systems and methods for treating disorders of the ear, nose and throat 1 2010
8,945,088 Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures 0 2010
8,870,893 Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat 0 2010
* 2010/0210,901 Devices, Systems and Methods For Diagnosing and Treating Sinusitis and Other Disorders of the Ears, Nose and/or Throat 36 2010
* 2011/0004,057 SYSTEMS AND METHODS FOR TRANSNASAL DILATION OF PASSAGEWAYS IN THE EAR, NOSE OR THROAT 45 2010
8,764,709 Devices, systems and methods for treating disorders of the ear, nose and throat 5 2010
9,155,492 Sinus illumination lightwire device 0 2010
* 2011/0160,740 Tissue Removal in The Paranasal Sinus and Nasal Cavity 4 2010
9,107,574 Endoscopic methods and devices for transnasal procedures 0 2011
8,968,269 Multi-conduit balloon catheter 0 2012
8,721,591 Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures 4 2012
8,905,922 Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat 1 2012
9,198,736 Adapter for attaching electromagnetic image guidance components to a medical device 0 2012
8,764,786 Balloon catheters and methods for treating paranasal sinuses 1 2012
9,308,361 Implantable devices and methods for treating sinusitis and other disorders 0 2013
9,084,876 Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders 0 2013
8,777,926 Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasel or paranasal structures 4 2013
9,072,626 System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx 0 2013
9,241,834 Devices, systems and methods for treating disorders of the ear, nose and throat 0 2014
9,220,879 Devices, systems and methods useable for treating sinusitis 0 2014
9,370,649 Devices, systems and methods useable for treating sinusitis 0 2015
 
Surgical Systems & Instruments, Inc. (1)
* 5,306,244 Method of guidewire insertion 57 1991
 
BRAINLAB AG (1)
6,464,662 Drug delivery and catheter systems, apparatus and processes 16 2000
 
Olympus Endo Technology America Inc. (1)
9,220,395 Rotate-to-advance catheterization system 0 2011
 
PINPOINT THERAPEUTICS, INC. (1)
6,699,231 Methods and apparatus for perfusion of isolated tissue structure 101 1998
 
ByPass, Inc. (2)
* 2007/0299,392 Material Delivery System 9 2005
* 2008/0140,001 Fluid Delivery Apparatus And Methods 4 2006
 
LARY RESEARCH & DEVELOPMENT, LLC (2)
7,985,200 Apparatus for delivering an intravascular drug 1 2006
* 2006/0189,930 Methods and Apparatus for Sclerosing the Wall of a Varicose Vein 8 2006
 
GE MARQUETTE MEDICAL SYSTEMS, INC. (1)
* 6,104,941 Physiological sensor 9 1998
 
Ad-Tech Medical Instrument Corp. (8)
* 7,241,283 Method for intracranial catheter treatment of brain tissue 27 2003
* 2004/0215,162 Intracranial catheter assembly for precise treatment of brain tissue 18 2003
7,465,292 Catheter system for intracranial treatment 4 2005
7,322,954 Catheter assembly for intracranial treatment using dual lumens 6 2005
7,255,686 Catheter assembly for intracranial treatment 5 2005
* 2006/0129,102 Catheter assembly for intracranial treatment 3 2005
* 2006/0079,857 Catheter system for intracranial treatment 3 2005
* 2006/0058,743 Depth probe for intracranial treatment 3 2005
 
DIETCH, LAURA N. (2)
* 2008/0243,068 METHODS AND APPARATUS FOR TREATMENT OF VENOUS INSUFFICIENCY 6 2006
* 2008/0140,002 SYSTEM FOR DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES WITH ACTUATING THREE DIMENSIONAL SURFACE 86 2007
 
YALE UNIVERSITY (3)
7,862,575 Vascular ablation apparatus and method 12 2003
* 2005/0055,040 Vascular ablation apparatus and method 13 2003
8,465,508 Vascular ablation apparatus and method 0 2007
 
TISSUE GENESIS, INC. (1)
* 2008/0058,763 Catheter for cell delivery 14 2007
 
J.W. MEDICAL SYSTEMS LTD. (18)
* 5,571,086 Method and apparatus for sequentially performing multiple intraluminal procedures 278 1994
7,147,655 Balloon catheter for multiple adjustable stent deployment 71 2002
8,157,851 Apparatus and methods for deployment of multiple custom-length prostheses 8 2005
7,938,851 Devices and methods for operating and controlling interventional apparatus 26 2005
7,320,702 Apparatus and methods for deployment of multiple custom-length prostheses (III) 77 2005
* 2006/0282,147 Apparatus and methods for deployment of multiple custom-length prostheses (1) 57 2005
* 2006/0282,150 Devices and methods for operating and controlling interventional apparatus 106 2005
* 2006/0282,148 Apparatus and methods for deployment of multiple custom-length prostheses (III) 4 2005
9,198,784 Apparatus and methods for deployment of multiple custom-length prostheses 0 2006
* 2007/0027,521 APPARATUS AND METHODS FOR DEPLOYMENT OF MULTIPLE CUSTOM-LENGTH PROSTHESES 42 2006
* 2007/0118,203 BALLOON CATHETER FOR MULTIPLE ADJUSTABLE STENT DEPLOYMENT 41 2007
9,370,642 Adjustable-length drug delivery balloon 0 2007
* 2008/0071,345 APPARATUS AND METHODS FOR DEPLOYMENT OF MULTIPLE CUSTOM-LENGTH PROSTHESES (III) 35 2007
8,147,536 Balloon catheter for multiple adjustable stent deployment 0 2009
8,142,487 Balloon catheter for multiple adjustable stent deployment 1 2009
* 2009/0299,458 BALLOON CATHETER FOR MULTIPLE ADJUSTABLE STENT DEPLOYMENT 0 2009
* 2009/0299,461 BALLOON CATHETER FOR MULTIPLE ADJUSTABLE STENT DEPLOYMENT 10 2009
9,119,739 Balloon catheter for multiple adjustable stent deployment 0 2013
 
BAYER HEALTHCARE LLC (2)
8,876,754 Catheter with filtering and sensing elements 0 2006
* 2008/0097,339 CATHETER WITH FILTERING AND SENSING ELEMENTS 2 2006
 
Cardiac Pacemakers, Inc. (2)
7,765,015 Lead with inflatable fixation mechanism 1 2007
* 2008/0172,118 LEAD WITH INFLATABLE FIXATION MECHANISM 10 2007
 
W. L. GORE & ASSOCIATES, INC. (23)
* 5,752,934 Balloon catheter device 93 1995
* 5,868,704 Balloon catheter device 94 1996
* 6,120,477 Balloon catheter device 180 1997
7,892,201 Balloon catheter and method of mounting same 4 1999
6,923,827 Balloon catheter device 33 2002
* 2003/0074,016 Balloon catheter device 10 2002
* 2005/0273,152 Balloon catheter device 7 2005
9,180,279 Inflatable imbibed polymer devices 0 2006
8,460,240 Inflatable toroidal-shaped balloons 4 2006
7,785,290 Non-shortening high angle wrapped balloons 8 2006
* 2008/0125,711 Catheter balloons with integrated non-distensible seals 11 2006
* 2008/0125,710 Inflatable imbibed polymer devices 0 2006
* 2008/0097,374 Inflatable shaped balloons 3 2006
* 2008/0097,301 Non-shortening high angle wrapped balloons 10 2006
* 2008/0086,083 Inflatable toroidal-shaped balloons 17 2006
* 2006/0271,091 Balloon catheter device 7 2006
* 2007/0061,000 BALLOON CATHETER DEVICE 6 2006
8,597,566 Non-shortening wrapped balloon 0 2009
8,636,690 Catheter balloons with integrated non-distensible seals 0 2009
* 2010/0049,123 Catheter balloons with integrated non-distensible seals 9 2009
8,585,640 Non-shortening high angle wrapped balloons 0 2010
* 2010/0262,178 Non-Shortening High Angle Wrapped Balloons 6 2010
9,126,007 Catheter balloons with integrated non-distensible seals 0 2014
 
Medtronic Vascular, Inc. (2)
7,753,876 Expandable jaw drug delivery catheter 6 2004
* 2010/0268,191 Drug Delivery Catheter using Frangible Microcapsules and Delivery Method 7 2009
 
VASCULAR BIOGENICS LTD. (3)
* 2011/0201,677 PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME 6 2011
* 2011/0207,985 PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS 8 2011
8,415,318 Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy 6 2011
 
KENSEY NASH CORPORATION (5)
6,709,427 Systems and methods for delivering agents into targeted tissue of a living being 35 1999
7,594,900 Systems and methods for delivering agents into targeted tissue of a living being 4 2002
* 2003/0191,449 Systems for delivering agents into targeted tissue of a living being 43 2003
7,419,482 Systems and methods for delivering agents into targeted tissue of a living being 3 2004
* 2010/0094,196 Systems and methods for delivering agents into targeted tissue of a living being 2 2009
 
Advanced Cardiovascular Systems, Inc. (51)
* 5,342,298 Automated fluid pressure control system 115 1992
* 5,415,637 Temporary stenting catheter with drug delivery capabilities 106 1993
* 5,611,775 Method of delivery therapeutic or diagnostic liquid into tissue surrounding a body lumen 161 1994
* 5,626,562 Drug delivery catheter 85 1994
* 5,865,794 Drug delivery catheter 20 1997
7,481,790 Vessel enlargement by arteriogenic factor delivery 1 2000
* 2002/0103,456 Vessel enlargement by arteriogenic factor delivery 1 2000
* 6,544,223 Balloon catheter for delivering therapeutic agents 290 2001
6,764,505 Variable surface area stent 340 2001
7,862,495 Radiation or drug delivery source with activity gradient to minimize edge effects 1 2001
* 2002/0183,581 Radiation or drug delivery source with activity gradient to minimize edge effects 224 2001
6,706,013 Variable length drug delivery catheter 168 2001
7,169,178 Stent with drug coating 83 2002
7,115,299 Balloon catheter for delivering therapeutic agents 25 2003
7,258,891 Stent mounting assembly and a method of using the same to coat a stent 24 2003
7,169,173 Composite stent with regioselective material and a method of forming the same 26 2003
7,198,675 Stent mandrel fixture and method for selectively coating surfaces of a stent 71 2003
* 2005/0069,630 Stent mandrel fixture and method for selectively coating surfaces of a stent 83 2003
7,563,324 System and method for coating an implantable medical device 54 2003
7,674,493 Method of making a variable surface area stent 1 2004
* 2005/0226,991 Methods for modifying balloon of a catheter assembly 15 2004
7,553,377 Apparatus and method for electrostatic coating of an abluminal stent surface 20 2004
* 2005/0265,960 Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same 53 2004
7,077,860 Method of reducing or eliminating thrombus formation 34 2004
7,297,159 Selective coating of medical devices 11 2004
7,648,727 Methods for manufacturing a coated stent-balloon assembly 7 2004
* 2006/0043,650 Methods for manufacturing a coated stent-balloon assembly 14 2004
7,632,307 Abluminal, multilayer coating constructs for drug-delivery stents 13 2004
* 2005/0288,481 Design of poly(ester amides) for the control of agent-release from polymeric compositions 60 2005
7,867,547 Selectively coating luminal surfaces of stents 0 2005
* 2007/0148,251 Nanoparticle releasing medical devices 64 2005
8,003,156 Rotatable support elements for stents 15 2006
* 2007/0259,099 Rotatable support elements for stents 11 2006
7,658,966 Balloon catheter for delivering therapeutic agents 10 2006
7,824,440 Stent with drug coating 3 2006
7,824,441 Stent with drug coating 3 2006
7,820,229 Method of coating a stent 4 2006
7,666,223 Stent with drug coating 6 2006
* 2007/0055,349 Stent with drug coating 48 2006
* 2007/0055,354 Stent with drug coating 46 2006
* 2007/0116,856 Composite stent with regioselective material 3 2006
* 2007/0118,212 Composite stent with regioselective material 10 2006
8,197,879 Method for selectively coating surfaces of a stent 1 2007
7,604,700 Stent mandrel fixture and method for selectively coating surfaces of a stent 2 2007
* 2007/0131,165 Stent mandrel fixture and method for selectively coating surfaces of a stent 4 2007
8,119,184 Method of making a variable surface area stent 2 2010
8,293,367 Nanoshells on polymers 1 2011
8,741,379 Rotatable support elements for stents 1 2011
8,637,110 Rotatable support elements for stents 1 2011
8,596,215 Rotatable support elements for stents 1 2011
8,465,789 Rotatable support elements for stents 1 2011
 
MEDTRONIC SPINE LLC (1)
* 2003/0023,260 Method and apparatus for dissecting tissue layers 12 2002
 
JAGOTEC AG (1)
6,852,708 Use of hyaluronic acid and forms to prevent the narrowing of the vascular walls 1 1997
 
INTERSECT ENT, INC. (5)
7,547,323 Stent for irrigation and delivery of medication 21 2006
* 2008/0097,354 Stent for irrigation and delivery of medication 4 2006
8,277,503 Stent for irrigation and delivery of medication 2 2009
8,277,504 Stent for irrigation and delivery of medication 2 2009
* 2009/0275,903 STENT FOR IRRIGATION AND DELIVERY OF MEDICATION 3 2009
 
COVIDIEN LP (1)
6,936,025 Thrombolysis device 39 2000
 
MEDTRONIC, INC. (11)
* 5,112,303 Tumor access device and method for delivering medication into a body cavity 94 1991
* 5,324,261 Drug delivery balloon catheter with line of weakness 131 1992
* 5,370,614 Method for making a drug delivery balloon catheter 119 1993
* 5,893,840 Releasable microcapsules on balloon catheters 186 1996
6,551,290 Catheter for target specific drug delivery 65 2000
6,945,969 Catheter for target specific drug delivery 38 2000
6,510,348 Perfusion lead and method of use 7 2000
6,697,677 System and method for placing a medical electrical lead 54 2001
6,567,704 Medical electrical lead and method of use 34 2001
7,153,292 Catheter for target specific drug delivery 1 2004
* 2004/0199,128 Catheter for target specific drug delivery 12 2004
 
Loyola University Chicago (1)
* 5,599,307 Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities 165 1995
 
FLOWMEDICA, INC. (2)
* 2009/0105,799 RENAL ASSESSMENT SYSTEMS AND METHODS 6 2008
* 2009/0318,857 SHEATH FOR USE IN PERIPHERAL INTERVENTIONS 1 2009
 
MEDTRONIC AVE, INC. (6)
* 5,904,670 Catheters and methods for guiding drugs and other agents to an intended site by deployable grooves 59 1996
6,280,413 Thrombolytic filtration and drug delivery catheter with a self-expanding portion 195 1997
* 5,854,822 Miniature x-ray device having cold cathode 42 1997
* 6,108,402 Diamond vacuum housing for miniature x-ray device 45 1998
* 6,069,938 Method and x-ray device using pulse high voltage source 29 1998
6,958,059 Methods and apparatuses for drug delivery to an intravascular occlusion 51 2001
 
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. (1)
* 5,306,250 Method and apparatus for intravascular drug delivery 245 1992
 
JPMORGAN CHASE BANK, N.A. (2)
6,716,252 Prostatic stent with localized tissue engaging anchoring means and methods for inhibiting obstruction of the prostatic urethra 25 2001
6,682,555 Methods for treating the prostate and inhibiting obstruction of the prostatic urethra using biodegradable stents 28 2001
 
AVENT, INC. (4)
* 7,465,291 Method of fluid delivery and catheters for use with same 13 2003
7,959,623 Method of fluid delivery and catheters for use with same 5 2008
* 2009/0093,790 METHOD OF FLUID DELIVERY AND CATHETERS FOR USE WITH SAME 1 2008
8,328,771 Method for fluid delivery and catheters for use with same 0 2011
 
COOK MEDICAL TECHNOLOGIES LLC (1)
8,469,943 Coated implantable medical device 0 2010
 
Radiance Medical Systems, Inc. (1)
* 6,027,487 Low profile infusion catheter 11 1996
 
SciMed (1)
* 5,554,119 Drug delivery catheter with manifold 214 1994
 
CALIBER THERAPEUTICS, INC. (3)
* 8,696,644 Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body 0 2010
* 2011/0166,547 Balloon Catheter Systems for Delivery of Dry Drug Delivery Vesicles to a Vessel in the Body 1 2010
* 8,715,230 Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body 0 2013
 
SCHNEIDER (USA) INC. (1)
* 5,772,632 Dilation-drug delivery catheter 48 1997
 
XRT CORP. (2)
* 5,713,853 Methods for treating thrombosis 155 1995
6,799,075 X-ray catheter 49 1996
 
CARDIOCOMMAND, INC. (1)
* 6,148,222 Esophageal catheters and method of use 121 1998
 
STRYKER EUROPEAN HOLDINGS I, LLC (4)
6,623,452 Drug delivery catheter having a highly compliant balloon with infusion holes 118 2000
7,758,541 Targeted drug delivery device and method 27 2004
8,206,346 Targeted drug delivery device and method 0 2010
* 2010/0286,655 Targeted Drug Delivery Device and Method 0 2010
 
MATRIGEN, INC. (1)
* 5,833,658 Catheters for the delivery of solutions and suspensions 60 1996
* Cited By Examiner