Monoclonal antibody against bone alkaline phosphatase

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United States of America Patent

PATENT NO 5087573
SERIAL NO

07162995

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Abstract

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Monoclonal antibody (mAb) 1E10.1 immunologically distinguishing human bone from human liver alkaline phosphatase isoenzymes by specific binding to the former and not the latter is developed. mAb 1B12 is useful as a positive control as it reacts with human bone and liver ALP. Also developed is mAb 2B11 (2B11.1) which is useful as a positive control in rat ALP systems as it reacts with rat bone, liver, kidney and cartilage ALP.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF KANSAS C/O OFFICE OF RESEARCH AND GRADUATE STUDIESRAINBOW BLVD AT 39TH STREET A CORP OF KS KANSAS CITY KS 66103

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, H Clarke Shawnee Mission, KS 4 16
Masuhara, Kensaku Kobe, JP 1 3

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