Preparation of a polymer/interleukin-2 conjugate
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United States of America Patent
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Feb 18, 1992
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N/A
app pub date -
Sep 29, 1989
filing date -
Jan 23, 1989
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Abstract
The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase its solubility, and increase its circulating in vivo half-life.
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