Use of substituted imidazoles
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United States of America Patent
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Feb 25, 1992
Grant Date -
N/A
app pub date -
Oct 17, 1990
filing date -
Oct 17, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention relates to local epidural or intraspinal use of compounds of the formula: ##STR1## where X is H or CH.sub.3 and R.sub.1 and R.sub.2, which can be the same or different, are each H or CH.sub.3 and their stereoisomers and their non-toxic, pharmaceutically acceptable salts. Especially useful are the compounds known under the generic names medetomidine ((.+-.)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole), dexmedetomidine (+)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole and detomidine 4-(2,3-dimethylbenzyl)-1H-imidazole.
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