Staurosporine derivatives substituted at methylamino nitrogen
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United States of America Patent
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Mar 3, 1992
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N/A
app pub date -
Mar 21, 1991
filing date -
Jun 15, 1987
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Abstract
N-substituted derivatives of staurosporine of the general formula [Stau]--N(CH.sub.3)--R (I) in which [Stau] represents a residue of the partial formula ##STR1## and R represents a hydrocarbyl radical R.sup.o or an acyl radical Ac, which radicals preferably have a maximum of 30 carbon atoms, and salts of compounds of the formula I having salt-forming properties, are distinguished as selective inhibitors of proteinkinase C. They are manufactured by conventional alkylation or acylation, respectively, of staurosporine.
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