Compounds which are useful, in particular, for radiotherapy or imaging of cancer
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United States of America Patent
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Mar 17, 1992
Grant Date -
N/A
app pub date -
Dec 15, 1988
filing date -
Apr 17, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compound useful particularly for the treatment by targetted radiotherapy or imaging of cancer, characterized in that the compound is comprised of a molecule susceptible of fixing itself or passing close to the DNA of the target cells, said molecule being radiolabelled with iodine 123. The invention also relates to new ligands specific of steroid hormone receivers useful for the targetted therapy or imaging particularly of cancer and presenting a structural base skeleton having the formula (I). According to the invention these ligands comprise particularly a) a hydroxyl or ketone function in position C.sub.3 ; b) a .beta. chloromethyl function on position C.sub.11 ; c) an .alpha. methyl or vinyl function on position C.sub.17 and d) a substituted radioactive iodine on an alkyl or alkenyl group attached to the skeleton, particularly methyl or vinyl.
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