Process for improving the biostability of tissue implant devices and bioprosthetic implants so produced
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United States of America Patent
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Apr 14, 1992
Grant Date -
N/A
app pub date -
Feb 21, 1991
filing date -
Feb 21, 1991
priority date (Note) -
Expired
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Abstract
Processes are disclosed for improving the biostability of tissue implant devices. The processes comprise methods for treating harvested tissue with calcification inhibitor, tissue crosslinking reagent, and reagents capable of forming additional tissue reaction sites providing bioprosthetic devices having enhanced amounts of tissue bound calcification inhibitor. After long-term implantation, the treated tissue remains calcification free and exhibits a high degree of physical stability which minimizes the risk of mechanical failure.
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