5-(phenylalkoxy)primaquine and 5[(heterocycle)alkoxy] primaquine compounds and their use for treatment of malaria
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United States of America Patent
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Apr 14, 1992
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N/A
app pub date -
Oct 16, 1990
filing date -
Mar 13, 1990
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Abstract
Improvement in the treatment of malaria has been demonstrated with 5-[(aryl)alkoxy] primaquine compounds and 5[(heterocycle)alkoxy] primaquine compounds. These primaquine related compounds are effective in malarial chemotherapy. The 5-arylalkoxy primaquine compounds of the invention are at least as effective in malarial treatment as the prior are 5-alkoxy primaquine compounds, but are not as toxic as the 5-alkoxy compounds at higher dosage ranges. The 5[(heterocycle)alkoxy] primaquine compounds show less toxicity than primaquine in blood schizonticidal studies and are comparable to the 5-arylalkoxy primaquine compounds in efficacy.
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