Platinum(II) complexes, their preparation and use as anti-tumor agents
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United States of America Patent
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Apr 14, 1992
Grant Date -
N/A
app pub date -
Nov 5, 1990
filing date -
Apr 1, 1988
priority date (Note) -
Expired
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Abstract
Compounds of formula I ##STR1## wherein R.sub.1 and R.sub.2, that can be the same or different, are hydrogen, alkyl, aryl, aralkyl groups or, if taken together, cycloalkyl groups; A is a carbon atom, a residue of 2,3-dioxybutandioic-2,4-dioxyphtalic acid or disubstituted malonic acid derivatives; n.sub.1 and n.sub.2 are selected in such a manner that the result of their addition is from 2 to 40; T.sub.1 and T.sub.2 that can be the same or different, are hydrogen, alkyl, benzyl, phenyl, acyl or cycloalkyl or a residue of formulae ##STR2## Compounds I are useful as anti-tumor agents in human therapy.
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