Heterocyclic compounds useful as 5-HT.sub.3 antagonists
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United States of America Patent
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Apr 21, 1992
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N/A
app pub date -
Dec 19, 1989
filing date -
Dec 24, 1987
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Abstract
Aryl ureas and carbamic acid derivatives of formula A--NHCW--Y--B and pharmaceutically acceptable salts thereof wherein A is a specified aromatic radical including 3,5-dichlorophenyl W is O or S Y is NH or O and B is a specified saturated azacyclic ring, e.g. tropan-3-yl or quinuclidin-3-yl, possess 5-HT.sub.3 -antagonistic activity and are, for example, useful in treatment of migraine, emesis, anxiety, gastro-intestinal disorders and as anti-psychotics.
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