Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
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United States of America Patent
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May 12, 1992
Grant Date -
N/A
app pub date -
Apr 23, 1990
filing date -
Apr 23, 1990
priority date (Note) -
Expired
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Abstract
The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist of blood-brain barrier permeability, such as N-acetyl [Phe.sup.8 (CH.sub.2 -NH)Arg.sup.9 ] bradykinin, to the individual. The bradykinin agonist of blood-brain barrier permeability is co-administered with the agent of interest into a blood vessel such as a vein. This co-administration allows the agent of interest to pass the blood-brain barrier into the brain compartment.
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