Method of enhancing the effect of cytotoxic agents
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United States of America Patent
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May 12, 1992
Issued Date -
N/A
app pub date -
Apr 4, 1988
filing date -
Feb 26, 1988
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Abstract
The activity of cytotoxic agents on target cells is enhanced through administration of a sensitizing agent to a patient prior to or simultaneously with administration of the cytotoxic agent. One or both of the two types of agents are attached to antibodies specific for the desired target cells, thereby enhancing the cytotoxic effect on target cells compared to non-target cells. The sensitizer and/or the cytotoxic agent may be attached to monoclonal antibodies specific for cancer cells to selectively eradicate the cancer cells while minimizing toxicity toward normal tissues.
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