Modified oligonucleotides
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United States of America Patent
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May 12, 1992
Grant Date -
N/A
app pub date -
Nov 14, 1988
filing date -
Nov 12, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides modified oligonucleotides, wherein, amongst the first four bases on the 5'-end, they have the base sequence AT or TA and, bound to one of the two O.sup.- groups of the 5'-phosphate group of the first nucleotide at the 5'-end of said oligonucleotide, they contain a radical of the general formula: ##STR1## in which R.sub.4 is a spacer group and R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms or alkyl or alkoxy radicals containing up to 3 carbon atoms. These modified oligonucleotides can be used for blocking the replication and/or expression of genes which have a sequence complementary with the modified oligonucleotides.
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