Conjugates having improved characteristics for in vivo administration
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United States of America Patent
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May 26, 1992
Grant Date -
N/A
app pub date -
Dec 29, 1989
filing date -
Dec 29, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Conjugates comprising a therapeutically effective proteinaceous active moiety linked to an albumin moiety which exhibit enhanced serum half-life and stability properties are disclosed. The conjugates may additionally comprise targeting moieties to facilitate selective localization of the active moiety at a target site. Conjugates of the present invention comprising an albumin moiety additionally exhibit reduced toxicity, yet maintain a high degree of selectivity and potency.
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