Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
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United States of America Patent
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Jun 16, 1992
Grant Date -
N/A
app pub date -
Mar 31, 1989
filing date -
Mar 31, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A controlled release device for the administration of biologically active growth hormone proteins or peptide fragments, and method of preparation thereof, wherein biologically active growth hormone is stabilized and release rate modulated by incorporation of a stabilizing compound. The controlled release devices are prepared by mixing a stabilizer, such as sucrose, with a biologically active growth hormone, such as bovine somatotropic hormone, in solution, lyophilizing, then incorporating the dried powder into a surface erodible, biocompatible polymeric matrix, such as a poly(anhydride) or poly(orthoester) matrix.
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