Method for the reduction of heterogeneity of monoclonal antibodies
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United States of America Patent
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Jun 30, 1992
Issued Date -
N/A
app pub date -
Jun 9, 1989
filing date -
Sep 28, 1988
priority date (Note) -
Expired
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Abstract
Novel methods for reducing the heterogeneity of secreted monoclonal antibodies are disclosed. The first method comprises incubating the heterogeneous antibodies at low pH for a length of time sufficient to convert the heterogeneous forms of antibodies into substantially homogeneous forms. Another method produces the same result using ascites fluid, while yet another method produces the same result using carboxypeptidase. The homogeneous antibodies can then be purified in high yield.
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