PDGF analogs and methods of use
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United States of America Patent
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Jul 7, 1992
Issued Date -
N/A
app pub date -
Aug 8, 1988
filing date -
Aug 13, 1986
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Proteins having substantially the same biological activity as PDGF are provided. In one aspect, a protein homodimer having two polypeptide chains is disclosed, each of the chains being a mosaic of amino acid sequences substantially identical to portions of the A- and B-chains of PDGF, the protein being chemotactic or mitogenic for fibroblasts. Therapeutic compositions comprising such proteins in combination with a physiologically acceptable carrier or diluent are also provided. Such therapeutic compositions may be used within methods for enhancing the wound-healing process in warm-blooded animals.
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