Process for the production of 3-1(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole

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United States of America Patent

PATENT NO 5128482
SERIAL NO

07642804

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Abstract

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The invention provides a process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole and certain salts and internal condensation products thereof. An unsaturated indolyl ester is reacted with ethylchloro(hydroxyimino)acetate in the presence of triethylamine in an organic solvent to cause a 1,3-dipolar addition reaction to form a di-ester. The di-ester is saponified to form a di-acid which di-acid is then reduced to form either the product indole or a salt thereof.

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Patent Owner(s)

  • TECHNOLOGY FINANCE CORPORATION (PROPRIETARY) LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bischofberger, Karl Pretoria, ZA 1 38
Olivier, Johan Pretoria, ZA 3 39

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