Method to stabilize basic fibroblast growth factor
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United States of America Patent
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Jul 14, 1992
Grant Date -
N/A
app pub date -
May 2, 1989
filing date -
May 2, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Treatment of basic fibroblast growth factor (bFGF) with organic disulfides, preferably glutathione disulfide, or with inorganic compounds of similar function results in a bFGF composition of enhanced stability and resistance to multimerization. The resulting stabilized form mimics the chromatographic behavior of bFGF as isolated from bovine pituitary.
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