Tablets of the hydrophilic matrix type based on salbutamol and a process for their preparation
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United States of America Patent
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Jul 21, 1992
Issued Date -
N/A
app pub date -
Oct 18, 1991
filing date -
Jul 16, 1987
priority date (Note) -
Expired
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Abstract
The present invention relates to tablets of the type which contain a homogeneous dispersion of an active principle based on salbutamol or on one of its derivatives in a hydrophilic matrix, ensuring: in vitro, long-term release of the active principle, which is constant and independent of pH, over a time interval of about 12 hours, in vivo, uptake kinetics of the active principle by the organism of zero order over a time interval of 6 hours, the said matrix containing at least one swelling agent and a diluent in a weight ratio of swelling agent/diluent lying between 0.2 and 0.6, and being preferably equal to about 0.4. The present invention also covers the process for the preparation of these tablets.
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