Method of providing a substrate with a layer comprising a polyvinyl based hydrogel and a biochemically active material
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United States of America Patent
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Jul 28, 1992
Grant Date -
N/A
app pub date -
Oct 10, 1989
filing date -
Oct 10, 1988
priority date (Note) -
Expired
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Abstract
Disclosed is a method of providing a substrate with a layer comprising a polyvinyl base hydrogel and a biochemically active material by photolithograhy, comprising coating the substrate by centrifugal force with an aqueous solution of a photosensitive hydrogel forming polymer, a crosslinking agent and a biochemically active material, drying said coating, exposing the coated substrate through a photomask to ultraviolet radiation and developing said exposed coating, which is characterized by applying to the substrate an aqueous solution comprising as the cross-linking agent a polyazonium compound and glutardialdehyde. Because of this specific combination of cross-linking agents superior properties with respect to the binding of the biochemically active material are obtained.
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