Process for activating a polymer surface for covalent bonding for subsequent coating with heparin or the like
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United States of America Patent
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Jul 28, 1992
Grant Date -
N/A
app pub date -
Feb 14, 1991
filing date -
Feb 15, 1990
priority date (Note) -
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Abstract
A dicarbonyl halide preferably a straight-chain-alkyl dicarbonyl dihalide, may be used to activate a substrate surface of preferably polyurethane or polyamide. Optionally, an amine-end blocked polymer may be reacted with the resulting activated surface by reaction between amine and dicarbonyl halide groups. Then, a material to be covalently bonded to said surface, such as heparin, may be reacted with free amine groups bonded to the surface by a carbodiimide process or the like.
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