Piezoelectric cell growth biosensing method using polymer-metabolic product complex interactions
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United States of America Patent
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Aug 4, 1992
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N/A
app pub date -
Jul 25, 1989
filing date -
Jul 25, 1989
priority date (Note) -
Expired
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Abstract
The invention relates to a piezoelectric biosensor device and also to a method and a system utilizing a piezoelectric biosensor device for detecting metabolic growth requirements, antibiotic responses, and the specific bacterial products of microorganisms. When a microorganism is grown in an appropriate nutrient medium containing a metabolic product responsive polymer, metabolic products of the organism acidify the medium and precipitate a polymer metabolic product complex which deposits or accumulates on the surface of a piezoelectric biosensor device. The mass change on the surface of the device resulting from this deposit produces a change in the resonant frequency of the piezoelectric biosensor device which can be used to determine the growth and type of microorganism.
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