Biphenyl-5,5'-bis-alkanoic acid derivatives, their production and aldose reductase inhibitors containing the same
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United States of America Patent
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Aug 4, 1992
Grant Date -
N/A
app pub date -
Aug 8, 1991
filing date -
Aug 8, 1990
priority date (Note) -
Expired
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Abstract
An aldose reductase inhibitor, comprising a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof as the effective component, in which R denotes an alkyl of C.sub.1-12, ##STR2## wherein X.sub.1 and X.sub.2 are same or different and are hydrogen or halogen, cyclohexylmethyl, cyclohexyl, tetra-hydro-2H-pyran-1-yl-methyl, carboxy-lower alkyl or cyclo-lower alkyl and n is 2 or 3. These compounds exhibit a superior aldose reductase inhibiting activity with simultaneous high stability, and are for use in the prevention and therapy of diabetic complications.
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