Manufacture of partially fused peptide pellet
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United States of America Patent
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Aug 11, 1992
Issued Date -
N/A
app pub date -
May 24, 1991
filing date -
Mar 2, 1988
priority date (Note) -
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status (Latency Note)
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Abstract
A bioerodible pellet capable of administering an even and continuous dose of a peptide over a period of up to a year, when subcutaneously implanted, is provided. The bioerodible implant is a partially-fused pellet, which pellet has a peptide drug homogeneously-bound in a matrix of a melted and recrystallized, nonpolymer carrier. Preferably, the nonpolymer carrier is a steroid and in particular is cholesterol or a cholesterol derivative. In one embodiment, the peptide drug is growth hormone-releasing hormone. A method for making the bioerodible pellet also is provided.
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