Polyamine conjugated oligonucleotides
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United States of America Patent
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Aug 11, 1992
Issued Date -
N/A
app pub date -
Jul 27, 1990
filing date -
Jul 27, 1990
priority date (Note) -
Expired
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Abstract
Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides targeted at the tat region of HIV comprise certain preferred embodiments.
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