Erythromycin derivatives
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United States of America Patent
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Aug 25, 1992
Grant Date -
N/A
app pub date -
Apr 18, 1990
filing date -
Apr 18, 1990
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Novel 6-deoxyerythromycin derivatives are disclosed, as are methods for their preparation and use as antiinfective agents. The compounds of the invention include 6-deoxyerythromycins and 6-deoxy-15-norerythromycins which are represented by the structural formula ##STR1## in which R.sub.1 is selected from OH and H, and R.sub.2 and R.sub.3 are independently selected from H and CH.sub.3, as well as the pharmaceutically acceptable salts and esters of the above compounds. Additionally disclosed are genetically modified microorganisms which produce the compounds of the invention and means for the preparation of those microorganisms.
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