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Abstract

A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted, or is a 5- or 6-membered monocyclic heteroaryl radical in which the single heteroatom is nitrogen, oxygen or sulfur, R2 is a lower alkyl radical, R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkylalkyl radical, or, together with the nitrogen atom to which they are attached, form a saturated 5- to 6-membered heterocycle comprising only one heteroatom, R5 is a 5- to 7-membered cycloalkyl radical, a phenyl radical or a 5- or 6-membered monocyclic heteroaryl radical, and W represents a group .dbd.CH--QH, or a heterocycle .dbd.C[Q--(CH2)n--Q], or a group .dbd.C.dbd.Q, in which groups Q is an oxygen or sulfur atom, n has the value 2 or 3, W being .dbd.C.dbd.Q only when R3 and R4 are not both hydrogen, and their additions salts with pharmaceutically acceptable acids. A pharmaceutical composition comprising a compound of general formula (I) with the above definitions for the treatment of diarrheal states.

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First Claim