Process for the preparation of anti-hypertensive benzopyran derivative
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United States of America Patent
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Sep 8, 1992
Grant Date -
N/A
app pub date -
Jun 25, 1990
filing date -
Jul 21, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A process is disclosed for the preparation of (.+-.)-6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrol idino)-2H-1-benzopyran-3-ol of the Formula (VI) ##STR1## from 4-cyanophenol of the Formula (I) ##STR2## which comprises reacting 4-cyanophenol of the Formula (I) with isoprene, followed with bromination and dehydrobromination steps with formation of intermediates to react with 2-pyrrolidone resulting in obtaining the compound of the Formula (VI).
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