Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing
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United States of America Patent
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Sep 22, 1992
Issued Date -
N/A
app pub date -
Nov 24, 1987
filing date -
May 22, 1984
priority date (Note) -
Expired
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Abstract
A method for maintaining intact, non-degraded von Willebrand factor by preventing the action of calcium activated protease(s) responsible for degradation of the factor. The action of the calcium activated protease(s) may be avoided by removing the blood platelet source of the protease(s), by filtering or centrifugal separation, or by inactivating the protease with a chelating agent removing the calcium, by a protease inhibitor, or an alkylating agent.
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