Method of producing secreted receptor analogs and biologically active peptide dimers
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United States of America Patent
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Oct 13, 1992
Grant Date -
N/A
app pub date -
May 2, 1989
filing date -
Jan 22, 1988
priority date (Note) -
Expired
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Abstract
Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.
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