Biodegradable microspheres as a carrier for macromolecules
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United States of America Patent
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Nov 3, 1992
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N/A
app pub date -
Jan 9, 1990
filing date -
May 16, 1986
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Expired
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Abstract
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.
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