Polymer bound elastase inhibitors
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United States of America Patent
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Nov 10, 1992
Issued Date -
N/A
app pub date -
Mar 25, 1992
filing date -
Sep 9, 1988
priority date (Note) -
Expired
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Abstract
Pharmaceutical compositions and methods of inhibiting the enzyme elastase and increasing the biological half-life and/or potency in terms of inhibitory activity of the enzyme elastase of peptide compounds is achieved by use of a polymer of the formula P--(L--R).sub.q wherein P is a polymer containing at least one unit of the formula (A.sub.n B.sub.n) wherein A.sub.n B.sub.n is substantially nonbiodegradable, and has an average molecular weight of about 1,000 to 5,000 daltons, L is a covalent bond or a linker group and R is a peptide.
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