2-heteroatom containing urea and thiourea ACAT inhibitors
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United States of America Patent
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Nov 10, 1992
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N/A
app pub date -
Jun 24, 1991
filing date -
Jun 24, 1991
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Abstract
The present invention provides N-substituted aryl-N'-heterocyclic substituted ureas and thioureas of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino, substituted amino, or a monocyclic heterocyclic, or a carboxy group; and Het is a substituted monocyclic heterocyclic group containing two hetero atoms selected from nitrogen, oxygen or sulfur; which are useful in treating hypercholesterolemia and atherosclerosis.
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