Method for reversibly arresting muscle activity
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United States of America Patent
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Nov 10, 1992
Issued Date -
N/A
app pub date -
Jun 12, 1991
filing date -
Nov 1, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Muscle activity can be reversibly arrested by administering a reagent, such as 2,3-butanedione monoxime (BDM), which selectively blocks the interaction of the contractile proteins actin and myosin. Muscle such as the heart is contacted with the reagent to arrest activity and, after surgery or transplantation, the reagent is removed from the muscle to restore muscle activity. The preferred reagent BDM has the following structure: ##STR1##
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