Method of inhibiting large cell formation
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United States of America Patent
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Nov 17, 1992
Grant Date -
N/A
app pub date -
Sep 10, 1990
filing date -
Jan 9, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to an anti-HIV agent comprising as an effective component a plasma protein of which the polarity of the amino group of the amino acid residue constituting the plasma protein is chemically modified into a negative moiety by a carboxylic acid, for example, by maleic anhydride or succinic anhydride. Plasma proteins modified with dicarboxylic anhydride, which are the effective components of the anti-HIV agent of this invention, inhibit the formation of large cells in mixed culturing of HIV infected cells and non-infected cells as well as the direct infection of helper T cells with HIV. They are very safe compounds and are expected to be applicable to the treatment of HIV infected patients.
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