Sequence-specific binding polymers for duplex nucleic acids
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United States of America Patent
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Nov 24, 1992
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app pub date -
Jun 20, 1991
filing date -
Dec 20, 1989
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Abstract
A polymer composition effective to bind in a sequence-specific manner to a target sequence of a duplex polynucleotide containing different Watson-Crick basepair oreientaions. The composition includes an uncharged backbone with 5- or 6-membered cyclic backbone structures and selected bases attached to the backbone structures effective to hydrogen bond specifically with different oriented basepairs in the target sequence.
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