Propenone oxime ethers, a method of preparing them, and pharmaceutical compositions containing them
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United States of America Patent
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Nov 24, 1992
Grant Date -
N/A
app pub date -
Dec 1, 1989
filing date -
Dec 2, 1988
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The invention relates to new propenone oxime ethers, a method of preparing them and pharmaceutical compositions containing them. Said new propenone oxime ethers have the formula ##STR1## in which--Ar and Ar' each independentlyl denotes a phenyl group non-substituted, mono or polysubstituted, a 9-anthryl group or a naphthyl group, a pyridyl, thienyl or furyl group; R.sub.1 R.sub.2 each independently denotes hydrogen, a C.sub.1 -C.sub.4 alkyl group or together with the N-atom to which they are bonded a 1-pyrrolidinyl, piperidino, morpholino or 1-piperazinyl group; M=H, Cl, Br or a C.sub.1 -C.sub.6 alkyl group n=2 or 3. The invention also deals with the salts of compounds of formula (I). Said compounds have good activity in the anti platelet-clotting tests and are also antagonists of the 5HT.sub.2 receptors.
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