Hirudin-coated biocompatible substance
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United States of America Patent
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Dec 1, 1992
Grant Date -
N/A
app pub date -
Aug 3, 1988
filing date -
Aug 3, 1988
priority date (Note) -
Expired
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Abstract
Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorpeoreal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or fragment thereof.
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