Covalently-linked complexes and methods for enhanced cytotoxicity and imaging

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United States of America Patent

PATENT NO 5169933
SERIAL NO

07390241

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Abstract

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Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.

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Patent Owner(s)

Patent OwnerAddress
NEORX CORPORATIONSEATTLE WA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abrams, Paul G Seattle, WA 22 771
Anderson, David C Seattle, WA 51 1858
Fritzberg, Alan R Edmonds, WA 58 1539
Morgan, Jr A Charles Edmonds, WA 14 614
Nichols, Everett J Seattle, WA 32 619

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