Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
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United States of America Patent
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Dec 22, 1992
Issued Date -
N/A
app pub date -
May 1, 1991
filing date -
Aug 21, 1989
priority date (Note) -
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Abstract
Injectable aqueous compositions comprising folic acid and leucovorin and their salts, optionally including benzyl alcohol, sodium chloride and agents for adjusting pH are stabilized and buffered in the range of 6 to 10 by adding a combination of tromethamine and monothioglycerol. Such compositions remain stable for prolonged periods even when exposed to sunlight.
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