Radiolabeled proteins for diagnostic or therapeutic use
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United States of America Patent
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Dec 29, 1992
Issued Date -
N/A
app pub date -
Jan 14, 1991
filing date -
Dec 29, 1989
priority date (Note) -
Expired
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Abstract
Chelating compounds of specified N.sub.2 S.sub.2 N.sub.3 S derived structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable ester orthioester linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution properties, including reduced localization within the intestines and kidneys.
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