Transgenic mice depleted in mature T-cells and methods for making transgenic mice
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United States of America Patent
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Dec 29, 1992
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N/A
app pub date -
Dec 5, 1988
filing date -
Dec 5, 1988
priority date (Note) -
Expired
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Abstract
Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.
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