Modified forms of reproductive hormones
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United States of America Patent
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Jan 5, 1993
Issued Date -
N/A
app pub date -
Jun 1, 1990
filing date -
Feb 21, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides recombinant native and mutein forms of human reproductive hormones with characteristic glycosylation patterns which are influential in the metabolic activity of the protein. The invention also provides recombinant mutant forms of the human alpha subunit common to FSH, LH, CG, and TSH, to obtain hormones which also have unique glycosylation patterns. Also provided are recombinant materials to produce these subunits separately or together to obtain complete heterodimeric hormones of regulated glycosylation pattern and activity. Modified forms of LH and FSH beta subunits which enhance the rate of dimerization and secretion of the dimers or individual chains are also disclosed.
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Family
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